Stuxnet is a malicious computer worm first uncovered on June 17, 2010, and thought to have been in development since at least 2005. Stuxnet targets supervisory control and data acquisition (SCADA) systems and is believed to be responsible for causing substantial damage to the Iran nuclear program. Although neither the United States nor Israel has openly admitted responsibility, multiple independent news organizations claim Stuxnet to be a cyberweapon built jointly by the two countries in a collaborative effort known as Operation Olympic Games. The program, started during the Bush administration, was rapidly expanded within the first months of Barack Obama's presidency.

Stuxnet specifically targets programmable logic controllers (PLCs), which allow the automation of electromechanical processes such as those used to control machinery and industrial processes including gas centrifuges for separating nuclear material. Exploiting four zero-day flaws in the systems, Stuxnet functions by targeting machines using the Microsoft Windows operating system and networks, then seeking out Siemens Step7 software. Stuxnet reportedly compromised Iranian PLCs, collecting information on industrial systems and causing the fast-spinning centrifuges to tear themselves apart. Stuxnet's design and architecture are not domain-specific and it could be tailored as a platform for attacking modern SCADA and PLC systems (e.g., in factory assembly lines or power plants), most of which are in Europe, Japan and the United States. Stuxnet reportedly destroyed almost one-fifth of Iran's nuclear centrifuges. Targeting industrial control systems, the worm infected over 200,000 computers and caused 1,000 machines to physically degrade.